Melanonychia 20 November 2021 Melanonychia is a black, brown or grey discoloration of the nail, with numerous causes, such as trauma, systemic disease, or medications. Related Articles: Glossary: Longitudinal MelanonychiaGlossary: Skin Cancer of the Nail MatrixGlossary: OnychosisAlternative Meanings: Melanonychia A condition characterized by dark pigmentation in the nail plate, which can occur in streaks or bands. While often harmless, it may be a sign of melanoma in some cases.